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    Science. 1993 Dec 17;262(5141):1889-92.

    Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.

    Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K.

    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032.

    Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

    PMID: 8266081 [PubMed - indexed for MEDLINE]

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