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J Mol Biol. 1993 Dec 20;234(4):946-50.

Shape complementarity at protein/protein interfaces.

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  • 1Biomolecular Research Institute, Parkville, Victoria, Australia.


A new statistic Sc, which has a number of advantages over other measures of packing, is used to examine the shape complementarity of protein/protein interfaces selected from the Brookhaven Protein Data Bank. It is shown using Sc that antibody/antigen interfaces as a whole exhibit poorer shape complementarity than is observed in other systems involving protein/protein interactions. This result can be understood in terms of the fundamentally different evolutionary history of particular antibody/antigen associations compared to other systems considered, and in terms of the differing chemical natures of the interfaces.

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