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J Oral Maxillofac Surg. 1994 Jan;52(1):49-51.

Polylactide inhibition of carcinoma cell growth in vitro.

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  • 1Orofacial Medicine Division, Head and Neck Center, Sisters of Charity Hospital, Buffalo, NY.


Normal fibroblasts and epithelial tumor cells were challenged by exposure for 24 hours to extracts of a pure metal, a metal alloy, and a polymer used in facial reconstruction to assess cellular growth effects. While none of these materials significantly altered fibroblast growth rates, poly-L-lactide inhibited carcinoma cell growth at 5.0% extract concentration. No carcinoma cell growth effects were seen from exposure to stainless steel or commercially pure titanium extracts.

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