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    Neuroreport. 1993 Sep 30;4(12):1343-6.

    Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

    Gregor P, O'Hara BF, Yang X, Uhl GR.

    Source

    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224.

    Abstract

    Molecular heterogeneity of kainate-selective glutamate receptor subunits GluR5 and GluR6 was revealed by identification of a human cDNA, GluR5-1d, and a murine cDNA, GluR6-2, that each encode subunits with novel carboxy-terminal sequences. Both GluR5-1d and GluR6-2 appear to be generated by alternative splicing at analogous sites 14 codons following the fourth putative transmembrane segment. The principal transcripts of GluR5 and GluR6 were detected by Northern analyses of several regions of mammalian brains as 4 and 6 kb bands, respectively. Potential roles for these receptors in development are indicated by detection of their mRNAs in mouse embryos of 11 days gestation. These findings add to the description of the remarkable diversity of glutamate receptor gene expression.

    PMID:
    8260617
    [PubMed - indexed for MEDLINE]

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      Cited by 1 PubMed Central article

      • Linkage and association of the glutamate receptor 6 gene with autism. [Mol Psychiatry. 2002]
        Linkage and association of the glutamate receptor 6 gene with autism.
        Jamain S, Betancur C, Quach H, Philippe A, Fellous M, Giros B, Gillberg C, Leboyer M, Bourgeron T, Paris Autism Research International Sibpair (PARIS) Study. Mol Psychiatry. 2002; 7(3):302-10.

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