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1: Nature. 1993 Dec 16;366(6456):643-54.Click here to read Links

Proteins regulating Ras and its relatives.

Boguski MS, McCormick F.

National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, Maryland 20894.

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.

PMID: 8259209 [PubMed - indexed for MEDLINE]