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Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Jun;13(6):354-5, 326.

[Effects of Salvia miltiorrhizae compositae on phosphoinositides metabolism in acute myocardial ischemia].

[Article in Chinese]

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  • 1Navy No. 414 Hospital, Nanjing.

Abstract

The effects of Salvia miltiorrhizae compositae (SMC) on phosphoinositides metabolism of acute myocardial ischemia in rats were studied. The results showed that the function of the phosphoinositide signaling system was enhanced 10 min. after acute myocardial ischemia. Both of the accumulations of phosphatidylinositol-4,5-biphosphate (PIP2) and inositol-1,4,5-triphosphate (IP3) were higher than those of the non-ischemic control group (P < 0.01, n = 7). The rise of the levels of PIP2 and IP3 caused by acute myocardial ischemia was remarkably inhibited by the SMC (2g/kg body wt.), and the levels of PIP2 and IP3 were lower than those of the ischemic group (P < 0.01, n = 7).

PMID:
8257842
[PubMed - indexed for MEDLINE]
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