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    Biochem Biophys Res Commun. 1993 Nov 30;197(1):263-70.

    Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.

    An S, Yang J, Xia M, Goetzl EJ.

    Source

    Department of Medicine, University of California, San Francisco 94143-0724.

    Abstract

    Prostaglandin E2 (PGE2) is a potent mediator in many human tissues, that is recognized by three distinct subtypes of receptors, designated EP1, EP2 and EP3. A cDNA from a human lung library encodes a 53 kDa protein of 88% homology with the mouse EP2 receptor. Human EP2 receptors in COS-7 cell transfectants bound [3H]-PGE2 with a mean Kd of 2.2 nM and native specificity, and transduced increases in the intra-cellular concentration of cyclic AMP, but not of Ca++. That most EP2 receptor mRNA is in lung, kidney, intestinal, glandular and immune tissues, is consistent with functional responses.

    PMID:
    8250933
    [PubMed - indexed for MEDLINE]

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