Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Am J Clin Nutr. 1993 Dec;58(6):846-52.

Dietary fat affects weight loss and adiposity during energy restriction in rats.

Author information

  • 1Medical Research Service, Department of Veterans' Affairs Medical Center, Hampton, VA 23667.


This study examined the effect of dietary fat during food restriction on weight loss, body composition, and adipose tissue lipoprotein lipase activity (ATLPL). Rats previously fed a high-fat diet were divided into four groups. One group served as baseline controls. The other three groups were fed diets of 12%, 28%, or 45% fat, restricted (R) in amounts to equal 75% of their previous ad libitum energy intake. After 10 wk, body weight loss and reduction of adiposity were significantly less in the 45%-R group compared with the 12%-R group (weight P < 0.05; adiposity P < 0.01). Rats fed restricted amounts of the high-fat diet (45%-R group) retained adiposity equivalent to baseline control rats. ATLPL activity was increased in the 45%-R group compared with baseline control rats. Further studies are needed in humans, but these results suggest that body composition will not be normalized with reduction of energy intake unless dietary fat is also reduced.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk