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Vaccine. 1993;11(11):1135-8.

Mucosal immunization with a subunit respiratory syncytial virus vaccine in mice.

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  • 1Department of Medicine, Rochester General Hospital, NY.


The protective efficacy of mucosal immunization with purified respiratory syncytial virus (RSV) fusion protein (F) using cholera toxin (CT) as an adjuvant was assessed in mice. Intranasal vaccination with F+CT induced F-specific serum IgG and nasal IgA and resulted in 75% protection from nasal virus replication compared with control mice. Intranasal CT+F with simultaneous parenteral F provided complete protection equivalent to intranasal live virus immunization.

[PubMed - indexed for MEDLINE]
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