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1: Vox Sang. 1993;65(3):190-3.Links

Effectiveness of four intravenous IgG preparations in prevention of phagocytosis of anti-Rh-(D)-coated erythrocytes by mononuclear phagocytes.

Sheth KV, al-Sedairy S, Lee J.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Four commercial intravenous immunoglobulin G (IGIV) preparations, Sandoglobulin (Sandoz), Intraglobin (Biotest), Gammonativ (Kabivitrum) and Gammaogard (Kabivitrum) showed percent inhibition of Fc receptor-mediated phagocytosis of anti-Rh(D)-coated erythrocytes as follows: 45 +/- 14 SD, 41 +/- 23 SD, 35 +/- 14 SD, 25 +/- 13 SD, respectively. Pre-incubation of Rh(D)-positive and antibody-coated Rh(D)-positive erythrocytes with IGIV did not lead to any inhibitory effects on phagocytosis. However, preincubation of mononuclear phagocytes with IGIV gave marked inhibition of phagocytosis of antibody-coated erythrocytes. In summary, all four IGIV preparations showed Fc receptor-mediated inhibition of phagocytosis of anti-Rh(D)-coated erythrocytes by mononuclear phagocytes.

PMID: 8249360 [PubMed - indexed for MEDLINE]