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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
Department of Laboratory Medicine, University of California, San Francisco 94143-0724.
We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1. Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors. Nrf1 activates transcription via NF-E2 binding sites in yeast cells. The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.
PMID: 8248256 [PubMed - indexed for MEDLINE]
PMCID: PMC47984
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Cited by 42 PubMed Central articles
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MCRS2 represses the transactivation activities of Nrf1.
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[BMC Cell Biol. 2009]
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The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.
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[Biochem J. 2007]
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Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I.
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[Proc Am Thorac Soc. 2006]
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