Isolation of cDNA encoding the human NF-E2 protein. [Proc Natl Acad Sci U S A. 1993]

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1: Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11366-70. Links

Isolation of cDNA encoding the human NF-E2 protein.

Chan JY, Han XL, Kan YW.

Department of Laboratory Medicine, University of California, San Francisco 94143-0724.

The human homolog of mouse NF-E2 was isolated from the K562 cell line and found to encode a member of the basic leucine-zipper family of DNA-binding regulatory proteins. The deduced amino acid sequence of the mouse and human proteins exhibited near identity. Comparison to the related protein, Nrf1, revealed significant homologies at isolated regions, particularly within the basic domain, suggesting that NF-E2 and Nrf1 are members of a distinct subfamily of basic leucine-zipper proteins that share similar DNA-binding properties. High levels of human NF-E2 mRNA were observed in human erythroleukemic cell lines examined. Extensive survey of human tissue samples found NF-E2 expression not limited to erythropoeitic organs. Expression in the colon and testis suggests that NF-E2 may participate in the regulation of genes other than globin.

PMID: 8248255 [PubMed - indexed for MEDLINE]

PMCID: PMC47983

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.
Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9926-30.

[Proc Natl Acad Sci U S A. 1994]
Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins.
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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
Proc Natl Acad Sci U S A. 1993 Dec 1; 90(23):11371-5.

[Proc Natl Acad Sci U S A. 1993]
ReviewThe NF-E2 transcription factor.
Int J Biochem Cell Biol. 1998 Apr; 30(4):429-32.

[Int J Biochem Cell Biol. 1998]
Review[Function of NF-E2-related transcription factors]
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[Seikagaku. 2000]
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