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    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71.

    A receptor for interleukin 10 is related to interferon receptors.

    Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW.

    Source

    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.

    Abstract

    We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways.

    PMID:
    8248239
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC47963
    Free PMC Article

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