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TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.
Center for Diabetes Research, University of Texas Southwestern Medical Center at Dallas 75235-9048.
It has been previously demonstrated that individuals with certain DR alleles have an increased relative risk of developing insulin-dependent diabetes mellitus (IDDM). The disease association is even stronger with certain DQ alleles but there is little association with DP providing a boundary of disease association to the 430 kb between DQ and DP. The recently described TAP (transporter associated with antigen processing) genes have been mapped approximately midway between DP and DQ. Therefore, it was of interest to determine if any TAP alleles were associated with IDDM. In addition to the alleles of TAP1 that have been described, others were identified during this study. Diabetics and normal controls were screened for TAP1 using single-stranded conformational polymorphism and relative risk was determined. In the same population group we have studied extensively in the past, we found a higher association of a TAP1 allele with IDDM than with any single HLA-DP allele but the risk was lower than with HLA-DQB1*0302. These data provide new limits for IDDM susceptibility to the 190-kb interval between TAP1 and HLA-DQB1.
PMID: 8248212 [PubMed - indexed for MEDLINE]
PMCID: PMC47925
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Cited by 3 PubMed Central articles
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Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison.
Sia C, Weinem M.
Rev Diabet Stud. 2005 Spring; 2(1):40-52. Epub 2005 May 10.
[Rev Diabet Stud. 2005]
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Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.
Schumacher TN, Kantesaria DV, Serreze DV, Roopenian DC, Ploegh HL.
Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):13004-8.
[Proc Natl Acad Sci U S A. 1994]
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Reproductive failure and the major histocompatibility complex.
Jin K, Ho HN, Speed TP, Gill TJ 3rd.
Am J Hum Genet. 1995 Jun; 56(6):1456-67.
[Am J Hum Genet. 1995]