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Hum Mol Genet. 1993 Sep;2(9):1449-53.

The density of transcriptional elements in promoter and non-promoter sequences.

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  • 1Theoretical Biology and Biophysics Group, Los Alamos National Labatory, NM 87545.


Using data currently available from transcriptional element (TE) databases, we have analyzed the density of these elements in both promoter and non-promoter sequences obtained from the GenBank sequence database. The density of putative TEs in non-promoter sequences was about 16% higher than that seen in pseudo-random DNA sequences. Promoter TE density from the transcription startsite to 100 basepairs upstream was found to be about 42% higher than in non-promoter sequences. However, the extensive overlap of putative TE densities between promoters and non-promoters confounds an attempt to use TE density as a simple discriminator.

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