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Curr Opin Genet Dev. 1993 Aug;3(4):595-605.

Evolution and role of Pax genes.

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  • Institute for Molecular Biology II, University of Z├╝rich, Switzerland.


Pax genes encode a class of highly conserved transcription factors containing a paired-domain. These factors play important roles in Drosophila and vertebrate development, for example, in segmentation and neurogenesis. Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information.

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