Hemolytic anemia associated with lead poisoning fr...[Am J Hematol. 1993]

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1: Am J Hematol. 1993 Dec;44(4):280-3.Links

Hemolytic anemia associated with lead poisoning from shotgun pellets and the response to Succimer treatment.

Aly MH, Kim HC, Renner SW, Boyarsky A, Kosmin M, Paglia DE.

Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.

Symptomatic lead poisoning with severe hemolytic anemia was observed in a patient with retained shot gun pellets. Surgical resection of the retained pellets and the use of a newer chelating agent, Succimer (2,3-dimercaptosuccinic acid) successfully lowered blood lead level. Hemolytic anemia was associated with deficient erythrocyte pyrimidine 5'-nucleotidase, and lowering of the lead level corrected the deficiency, suggesting that the enzyme deficiency is responsible for the hemolysis associated with lead poisoning. This case illustrates that retained lead pellets from shotgun wounds can cause severe lead poisoning.

PMID: 8238001 [PubMed - indexed for MEDLINE]

Gunshot-induced plumbism in an adult male. [J Natl Med Assoc. 2003]
The treatment of lead poisoning from gunshot wounds with succimer (DMSA) [J Toxicol Clin Toxicol. 1994]
Toxic lead levels treated with 2,3-dimercaptosuccinic acid and surgery. [J Trauma. 1999]
Hemolytic anemia following succimer administration in a glucose-6-phosphate dehydrogenase deficient patient. [J Toxicol Clin Toxicol. 1994]
Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines. [J Clin Invest. 1976]
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Hemolytic anemia associated with lead poisoning from shotgun pellets and the response to Succimer treatment.

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