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J Vasc Surg. 1993 Nov;18(5):858-66.

The preservation of renal function by isovolemic hemodilution during aortic operations.

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  • 1Department of Vascular Surgery, Manchester Royal Infirmary, United Kingdom.

Abstract

PURPOSE:

In an investigation of the effects of isovolemic hemodilution, 39 consecutive patients undergoing elective infrarenal aortic operation had detailed measurements of renal function, renal artery blood flow, and cardiac hemodynamics.

METHODS:

The patients were randomly allocated to receive acute preoperative isovolemic hemodilution to a hematocrit of 28%, with 20 patients receiving hemodilution and 19 being control subjects.

RESULTS:

Twelve (63%) of the control group had renal impairment, compared with only four (20% in the group receiving hemodilution (p < 0.01). Hemodilution also prevented the fall in cardiac output induced by cross-clamping (p < 0.01) and significantly reduced the need for transfusion of donor blood (p < 0.01).

CONCLUSIONS:

Acute isovolemic hemodilution is clearly a useful adjunct in the management of patients undergoing elective aortic operation.

PMID:
8230574
[PubMed - indexed for MEDLINE]
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