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J Comput Assist Tomogr. 1993 Nov-Dec;17(6):940-4.

Gd-DTPA enhancement of CSF in meningeal carcinomatosis.

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  • 1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105.

Abstract

OBJECTIVE:

We report four cases of CSF enhancement secondary to meningeal carcinomatosis observed during MRI. Only one case has been reported previously.

MATERIALS AND METHODS:

Four patients ranging from 4 to 20 years of age, and all having primary or secondary CNS neoplasms, were examined by cranial and/or spinal MRI before and after Gd-DTPA administration. Three of the patients had additional delayed imaging, and subtraction was used in one case.

RESULTS:

All four patients demonstrated CSF enhancement after Gd-DTPA administration, which increased on delayed imaging and was more apparent following subtraction. Three of the four patients died within 5 months of the MRI examination.

CONCLUSION:

CSF enhancement is uncommon, but when seen indicates massive tumor that coats the surface of the CNS. Detection of CNS enhancement may alter therapy; however prognosis may be poor when CSF enhancement is present. Delayed imaging and subtraction may improve detection of CSF enhancement.

PMID:
8227581
[PubMed - indexed for MEDLINE]
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