Changes in cerebral blood volume and vascular mean transit time during induced cerebral seizures

Radiology. 1976 Oct;121(1):105-9. doi: 10.1148/121.1.105.

Abstract

The relationship of the mean transit time of the vascular indicator C15O-labeled hemoglobin (tco) and the cerebral blood volume (CBV) as measured by stimulated x-ray fluorescence, to the mean arterial blood pressure (MABP) was examined in rhesus monkeys before and during experiment cerebral seizures. The results demonstrate a marked increase in CBV and a decrease in tco. A substantial portion of these changes is the passive accompaniment of the associated increase in MABP.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Pressure
  • Blood Volume*
  • Brain / blood supply*
  • Carbon Dioxide / blood
  • Carboxyhemoglobin
  • Cerebrovascular Circulation*
  • Epilepsy / chemically induced
  • Epilepsy / physiopathology*
  • Haplorhini
  • Macaca mulatta
  • Partial Pressure
  • Pentylenetetrazole
  • Time Factors

Substances

  • Carbon Dioxide
  • Carboxyhemoglobin
  • Pentylenetetrazole