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Clin Orthop Relat Res. 1993 Nov;(296):295-300.

Bone morphogenetic protein-induced muscle- and synovium-derived cartilage differentiation in vitro.

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  • 1Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.


Muscle- and synovium-derived mesenchymal-type cells differentiated into cartilage in response to a coating of partially purified rabbit bone morphogenetic protein (BMP) on a substratum of plastic. Observed by means of phase contrast microscopy, light microscope histochemistry, and electron microscopy, the sequence of events on a BMP-coated plastic substratum is the same as that observed on a substratum of bone matrix. The plastic eliminates the possibility of any endogenous allogeneic matrix-derived BMP contaminating the system. The differentiation of cartilage from synoviocytes and subsynovial cells resembles the pathologic process occurring in human chondromatosis.

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