Immunol Today. 1993 Sep;14(9):426-30.

Defining criteria for autoimmune diseases (Witebsky's postulates revisited)

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Dept of Immunology and Infectious Diseases, Johns Hopkins University, Baltimore, MD 21205.

Abstract

With new knowledge gained from molecular biology and hybridoma technology, as well as the original Witebsky postulates, we propose that three types of evidence can be marshalled to establish that a human disease is autoimmune in origin. They include direct evidence from transfer of pathogenic antibody or pathogenic T cells; indirect evidence based on reproduction of the autoimmune disease in experimental animals; and circumstantial evidence from clinical clues.

Comment in

Defining criteria for autoimmune diseases. [Immunol Today. 1994]
Defining criteria for autoimmune diseases.Marmont AM. Immunol Today. 1994 Aug; 15(8):388.
Autoantibody and autoimmune disease. [Immunol Today. 1994]
Autoantibody and autoimmune disease.Kaushik A. Immunol Today. 1994 Jul; 15(7):340-1.

PMID:: 8216719; [PubMed - indexed for MEDLINE]

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Defining criteria for autoimmune diseases (Witebsky's postulates revisited)
Defining criteria for autoimmune diseases (Witebsky's postulates revisited)
Immunol Today. 1993 Sep ;14(9):426-30.

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