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Ann Neurol. 1993 Oct;34(4):622-5.

Long-term follow-up of 121 patients with benign fasciculations.

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  • 1Mayo Clinic, Department of Neurology, Rochester, MN 55905.


Using the case records of Mayo Clinic patients, 121 patients with a diagnosis of benign fasciculations were identified. All had a normal neurological examination and normal electrophysiological studies, except for fasciculation potentials. Interviews by telephone were conducted 2 to 32 years after diagnosis. None of the patients developed symptomatic motor neuron disease. Forty individuals were in health care careers. A subset of 19 patients described acute onset of fasciculations following a viral infection. Benign fasciculations are not a preclude to progressive motor neuron disease.

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