Eosinophilic sclerosing cholangitis associated with hypereosinophilic syndrome

Am J Gastroenterol. 1993 Oct;88(10):1764-9.

Abstract

We describe the case of a 41-yr-old man who presented with signs and symptoms of cholestasis including abdominal pain, jaundice, and fever, with peripheral eosinophilia of 10% and bone marrow eosinophilia. Liver biopsy revealed an eosinophilic infiltrate and an ERCP demonstrated bile duct changes, compatible with primary sclerosing cholangitis (PSC). After treatment with prednisone and ursodeoxycholic acid, the patient's liver profile tests returned to normal, the ERCP changes resolved, and all symptoms disappeared. A literature review has not shown any previous reports of reversible sclerosing cholangitis, secondary to eosinophilic infiltration. The purpose of this report is to describe eosinophilic cholangitis, an entity that mimics PSC in the context of the hypereosinophilic syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cholangitis, Sclerosing / etiology*
  • Cholangitis, Sclerosing / pathology
  • Humans
  • Hypereosinophilic Syndrome / complications*
  • Hypereosinophilic Syndrome / pathology
  • Male