Trends Biochem Sci. 1993 Jul;18(7):260-3.

The leucine-responsive regulatory protein: more than a regulator?

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Institut Jacques Monod, (CNRS, Université Paris, France.

Abstract

The leucine-responsive regulatory protein (Lrp) is the regulator of the recently discovered leucine/Lrp regulon in Escherichia coli. Like other global regulators, it regulates the expression of 35 or more specific target operons. Studies of this global response have led to the suggestion that Lrp--and perhaps some other gene regulators--may also participate in the maintenance of chromosome structure and organization.

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Review The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. [Microbiol Rev. 1994]
Review The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.
Calvo JM, Matthews RG. Microbiol Rev. 1994 Sep; 58(3):466-90.
Review Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli. [Annu Rev Microbiol. 1995]
Review Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli.
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van der Woude MW, Low DA. Mol Microbiol. 1994 Feb; 11(4):605-18.
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A nucleoprotein activation complex between the leucine-responsive regulatory protein and DNA upstream of the gltBDF operon in Escherichia coli.
Wiese DE 2nd, Ernsting BR, Blumenthal RM, Matthews RG. J Mol Biol. 1997 Jul 11; 270(2):152-68.
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Use of an inducible regulatory protein to identify members of a regulon: application to the regulon controlled by the leucine-responsive regulatory protein (Lrp) in Escherichia coli.
Bhagwat SP, Rice MR, Matthews RG, Blumenthal RM. J Bacteriol. 1997 Oct; 179(20):6254-63.

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Cited by 21 PubMed Central articles

Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus. [J Bacteriol. 2011]
Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus.
Hart BR, Mishra PK, Lintner RE, Hinerman JM, Herr AB, Blumenthal RM. J Bacteriol. 2011 Aug; 193(15):3794-803. Epub 2011 Jun 3.
Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations. [BMC Syst Biol. 2009]
Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations.
Zare H, Sangurdekar D, Srivastava P, Kaveh M, Khodursky A. BMC Syst Biol. 2009 Apr 14; 3:39. Epub 2009 Apr 14.
Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium. [J Bacteriol. 2009]
Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium.
Baek CH, Wang S, Roland KL, Curtiss R 3rd. J Bacteriol. 2009 Feb; 191(4):1278-92. Epub 2008 Dec 12.

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