The effector interactions of p21ras

M S Marshall

doi:10.1016/0968-0004(93)90175-m

The effector interactions of p21ras

Trends Biochem Sci. 1993 Jul;18(7):250-4. doi: 10.1016/0968-0004(93)90175-m.

Author

M S Marshall¹

Affiliation

¹ Department of Medicine, Indiana University School of Medicine, Indianapolis.

PMID: 8212134
DOI: 10.1016/0968-0004(93)90175-m

Abstract

Genetic, physical and biochemical methods have been used successfully to identify discrete regions of the p21ras protein involved in protein-protein interactions. Of special interest are the effector residues of p21ras, which are essential for downstream signalling. This review details current understanding of what these residues are and how they bind and activate proteins essential to the ras pathway.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
GTPase-Activating Proteins
Genes, ras
Molecular Sequence Data
Mutagenesis, Site-Directed
Protein Binding
Protein Structure, Tertiary
Proteins / genetics
Proteins / metabolism*
Proto-Oncogene Proteins p21(ras) / genetics
Proto-Oncogene Proteins p21(ras) / metabolism*
Signal Transduction
ras GTPase-Activating Proteins

Substances

GTPase-Activating Proteins
Proteins
ras GTPase-Activating Proteins
Proto-Oncogene Proteins p21(ras)