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Am J Physiol. 1994 May;266(5 Pt 2):R1716-9.

A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila.

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  • 1Department of Cell Biology, University of Glasgow, United Kingdom.


The nitric oxide (NO) signaling pathway plays major roles in the vertebrate vascular, nervous, and immune systems. Here we present evidence that all the elements in the NO pathway are present in, and act to control epithelial fluid secretion by, the Malpighian tubules of an insect, Drosophila melanogaster. This finding will allow both a physiological and a molecular genetic dissection of the NO pathway in the same tissue.

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