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Nature. 1994 Jun 16;369(6481):533-8.

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

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  • 1Department of Molecular Biology, Genentech, South San Francisco, California 94080.

Abstract

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

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PMID:
8202154
[PubMed - indexed for MEDLINE]
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