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Nature. 1994 Jun 16;369(6481):519-20.
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
de Sauvage FJ,
Hass PE,
Spencer SD,
Malloy BE,
Gurney AL,
Spencer SA,
Darbonne WC,
Henzel WJ,
Wong SC,
Kuang WJ, et al.
Department of Molecular Biology, Genentech, South San Francisco, California 94080.
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
PMID: 8202154 [PubMed - indexed for MEDLINE]
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