Send to

Choose Destination
See comment in PubMed Commons below
Nature. 1994 Jun 16;369(6481):533-8.

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

Author information

  • 1Department of Molecular Biology, Genentech, South San Francisco, California 94080.


Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

Comment in

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk