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Can J Surg. 1994 Jun;37(3):245-9.

Invasive Clostridium septicum infection in association with colorectal carcinoma.

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  • 1Department of Surgery, University of Ottawa, Ottawa General Hospital, Ont.


The association between invasive Clostridium septicum infection and colorectal carcinoma is examined by the presentation of three cases and a review of the literature. In the first two cases the patients presented with nontraumatic metastatic clostridial gas gangrene. In the third case a patient with chemotherapy-induced myelosuppression from concomitant multiple myeloma had a necrotizing transmural infection of the right colon. The apparent portal of entry of Clostridium septicum was an occult carcinoma of the ascending colon. The increasing evidence for a strong link between this organism and some cases of neutropenic enterocolitis is reviewed.

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