Your browser version may not work well with NCBI's Web applications. More information here...
1: Science. 1994 Jun 3;264(5164):1455-8.Click here to read Links

Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription.

Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M.

Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA.

The estrogen receptor is a transcription factor which, when bound to estradiol, binds DNA and regulates expression of estrogen-responsive genes. A 160-kilodalton estrogen receptor-associated protein, ERAP160, was identified that exhibits estradiol-dependent binding to the receptor. Mutational analysis of the receptor shows that its ability to activate transcription parallels its ability to bind ERAP160. Antiestrogens are unable to promote ERAP160 binding and can block the estrogen-dependent interaction of the receptor and ERAP160 in a dose-dependent manner. This evidence suggests that ERAP160 may mediate estradiol-dependent transcriptional activation by the estrogen receptor. Furthermore, the ability of antiestrogens to block estrogen receptor-ERAP160 complex formation could account for their therapeutic effects in breast cancer.

PMID: 8197458 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Estrogen (Cenestin® , Enjuvia® , Estrace® , ...)

    Estrogen is used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause ('change of life', the end of monthly menstrual periods). Some brands of estrogen...

  • Tamoxifen (Nolvadex® )

    Your doctor has prescribed tamoxifen for you. Tamoxifen comes as a tablet to take by mouth.

  • Source: AHFS Consumer Medication Information