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Nature. 1994 Jun 2;369(6479):371-8.

Complete DNA sequence of yeast chromosome XI.

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  • 1Unité de Génétique Moléculaire des Levures (URA 1149 du CNRS and UFR927 University P.M. Curie), Départment de Biologie Moléculaire, Insitut Pasteur, Paris, France.


The complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome XI has been determined. In addition to a compact arrangement of potential protein coding sequences, the 666,448-base-pair sequence has revealed general chromosome patterns; in particular, alternating regional variations in average base composition correlate with variations in local gene density along the chromosome. Significant discrepancies with the previously published genetic map demonstrate the need for using independent physical mapping criteria.

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