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1: Genomics. 1994 Jan 15;19(2):379-81.Click here to read Links

Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7).

Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S.

Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037.

We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha 7 neuronal nicotinic subunit (90%). We have mapped the human alpha 7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

PMID: 8188270 [PubMed - indexed for MEDLINE]