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Trends Pharmacol Sci. 1994 Mar;15(3):77-83.

Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

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  • 1Department of Biomedical Sciences, CNR Centre for the Study of Mitochondrial Physiology, University of Padova, Italy.


Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation of a number of Ca(2+)-permeable channels, the channels that are controlled by the Ca2+ content of the intracellular stores have recently received much attention. In this review, Cristina Fasolato, Barbara Innocenti and Tullio Pozzan summarize the characteristics of this Ca(2+)-influx pathway and discuss the hypotheses about its mechanism of activation and its relationship with other receptor-activated Ca2+ channels.

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