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    Eur Arch Psychiatry Clin Neurosci. 1994;243(5):291-2.

    Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.

    Czech C, Förstl H, Hentschel F, Mönning U, Besthorn C, Geiger-Kabisch C, Sattel H, Masters C, Beyreuther K.

    Center for Molecular Biology, Heidelberg, Germany.

    The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.

    PMID: 8172944 [PubMed - indexed for MEDLINE]

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