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Science. 1994 Apr 29;264(5159):719-25.

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.

Author information

  • 1Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

Abstract

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.

PMID:
8171325
[PubMed - indexed for MEDLINE]
PMCID:
PMC3839659
Free PMC Article

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