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    Science. 1994 Apr 29;264(5159):719-25.

    Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.

    Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS.

    Source

    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

    Abstract

    In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.

    PMID:
    8171325
    [PubMed - indexed for MEDLINE]

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