Cell. 1994 Apr 22;77(2):307-16.

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.

Golub TR, Barker GF, Lovett M, Gilliland DG.

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Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Abstract

Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). CMML thus offers an opportunity to study early genetic events in the transition to AML. A recently recognized subgroup of CMML has a t(5;12)(q33;p13) balanced translocation. We report that the consequence of the t(5;12) translocation is expression of a fusion transcript in which the tyrosine kinase domain of the platelet-derived growth factor receptor beta (PDGFR beta) on chromosome 5 is coupled to a novel ets-like gene, tel, on chromosome 12. The tel-PDGFR beta fusion demonstrates the oncogenic potential of PDGFR beta and may provide a paradigm for early events in the pathogenesis of AML.

PMID:: 8168137; [PubMed - indexed for MEDLINE]

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TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13). [Blood. 1995]
TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13).
Wlodarska I, Mecucci C, Marynen P, Guo C, Franckx D, La Starza R, Aventin A, Bosly A, Martelli MF, Cassiman JJ. Blood. 1995 May 15; 85(10):2848-52.
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. [Oncogene. 1995]
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.
Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A. Oncogene. 1995 Apr 20; 10(8):1511-9.
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. [Proc Natl Acad Sci U S A. 1996]
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.
Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14845-50.
Review The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms. [Curr Top Microbiol Immunol. 1997]
Review The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms.
Golub TR, Barker GF, Stegmaier K, Gilliland DG. Curr Top Microbiol Immunol. 1997; 220:67-79.
Review Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms. [Curr Top Microbiol Immunol. 1996]
Review Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms.
Golub TR, Barker GF, Stegmaier K, Gilliland DG. Curr Top Microbiol Immunol. 1996; 211:279-88.

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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomono...
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.
Cell. 1994 Apr 22 ;77(2):307-16.

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