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Am J Psychiatry. 1994 May;151(5):756-9.

Optimal drug and behavior therapy for treatment-refractory schizophrenic patients.

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  • 1Camarillo-UCLA Research Center, Camarillo State Hospital, CA 93011-6022.


Thirteen treatment-refractory schizophrenic patients (10 men and three women) who were receiving more than 50 mg/day of haloperidol and who had been hospitalized for more than 1 year successfully tolerated a mean dose reduction of 63% with consequent improvement in psychopathology and side effects. The addition of intensive behavior therapy to the optimal dose of haloperidol yielded further improvements in functional behavior, such as self-care and social interaction.

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