Department of Pediatrics, Hamamatsu University School of Medicine.
Fludrocortisone acetate (Florinef), a 9 alpha-fluorinated derivative of hydrocortisone, has strong mineralocorticoid activity. From the calculated values in a tracer study, the divided dose regimen is recommended. Florinef has been widely used in the treatment of salt-wasting congenital adrenal hyperplasia (CAH). A tentative guideline for the treatment of salt-wasting CAH was described and its usefulness was discussed.