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Chest. 1994 Apr;105(4):1273-5.

Left ventricular remodeling in valvular aortic stenosis. Echocardiographic and clinical changes in two patients during follow-up.

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  • 1Division of Cardiology, S. Orsola-Fatebenefratelli Hospital, Brescia, Italy.


Left ventricular (LV) response to chronic pressure overload of aortic stenosis (AS) is usually characterized by an increase of wall thickness without cavity enlargement ("concentric hypertrophy"). During follow-up, two patients with AS developed relevant structural and functional changes of the left ventricle, ie, progressive LV dilatation, wall thinning, and reduction of systolic performance. At the same time, the patients had clinical symptoms of congestive heart failure. The pathophysiologic relevance of this form of LV remodeling in AS is discussed.

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