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Trends Biochem Sci. 1994 Feb;19(2):83-6.

Xeroderma pigmentosum and nucleotide excision repair of DNA.

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  • 1Institute of Molecular and Cellular Biology, Osaka University, Japan.


Nucleotide excision repair is a versatile strategy for removing DNA damage from the genome. Tremendous progress in understanding this process has been made in the last few years, and the field continues to develop rapidly. Exciting connections have emerged between nucleotide excision repair, transcription, and DNA replication, but many mysteries remain concerning the biochemical details of the mechanism, the connection with several human inherited syndromes, and the role of DNA repair in preventing cancer.

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