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    Science. 1994 Apr 22;264(5158):582-6.

    Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.

    Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ.

    Source

    Department of Surgery, Duke University Medical Center, Durham, NC 27710.

    Abstract

    Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.

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    PMID:
    8160017
    [PubMed - indexed for MEDLINE]

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