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Science. 1994 Apr 15;264(5157):430-3.

Association of intestinal peptide transport with a protein related to the cadherin superfamily.

Author information

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.

Abstract

The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption of beta-lactam antibiotics and angiotensin-converting enzyme inhibitors from the intestine into enterocytes lining the luminal wall. A monoclonal antibody that blocked uptake of cephalexin was used to identify and clone a gene that encodes an approximately 92-kilodalton membrane protein that was associated with the acquisition of peptide transport activity by transport-deficient cells. The amino acid sequence deduced from the complementary DNA sequence of the cloned gene indicated that this transport-associated protein shares several conserved structural elements with the cadherin superfamily of calcium-dependent, cell-cell adhesion proteins.

PMID:
8153632
[PubMed - indexed for MEDLINE]
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