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Radiology. 1994 May;191(2):569-72.

Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy.

Author information

  • 1Department of Radiation Oncology, Kaiser Permanente Medical Center, Los Angeles, CA 90027.

Abstract

PURPOSE:

To determine the efficacy of a standardized protocol of chemotherapy and low-dose radiation therapy in treatment of patients with anal canal cancer.

MATERIALS AND METHODS:

Forty-two consecutive patients with anal canal cancer were treated with 15 fractions of 30-Gy photon beam radiation therapy administered anteroposterior-posteroanterior in conjunction with chemotherapy with 5-fluorouracil and mitomycin C. Survival analysis was performed with the lifetest procedure.

RESULTS:

In patients with stage T1 and T2 tumors, 26 of 29 (90%) were free of disease after chemotherapy and radiation therapy and had no recurrent tumors. In patients with stage T3 and T4 tumors, five of 13 (38%) were free of disease after therapy and had no recurrences.

CONCLUSION:

This therapy is effective for epidermoid cancers of the anal canal that are smaller than 5 cm regardless of nodal status. Tumors larger than this or that invade adjacent structures are not adequately controlled with this protocol.

PMID:
8153343
[PubMed - indexed for MEDLINE]
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