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J Virol. 1994 May;68(5):3391-6.

Identification of minireovirus as a Norwalk-like virus in pediatric patients with gastroenteritis.

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  • 1Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.


In 1977, 30- to 32-nm virus-like particles, named minireovirus because of their unique morphologic appearance, were detected by electron microscopy in the stools of infants and young children with gastroenteritis. Sequence analysis of approximately 2,800 consecutive bases derived from overlapping PCR clones of a recent minireovirus clinical isolate showed 52% nucleotide sequence identity with the Norwalk virus sequence and, in addition, demonstrated that the genomic organizations of these two viruses were similar. Our data show that minireovirus is a Norwalk-like virus and should now also be included in the Caliciviridae family.

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