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J Affect Disord. 1994 Jan;30(1):35-46.

Temperament predicts clomipramine and desipramine response in major depression.

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  • 1University Department of Psychological Medicine, Christchurch School of Medicine, New Zealand.

Abstract

Clinical predictors of drug response in major depression have been weak and inconsistent. Eighty-four patients suffering from a current major depressive episode completed a 6-week double-blind trial of either clomipramine or desipramine. Temperament, as measured by the Tridimensional Personality Questionnaire, accounted for 35% of the variance in treatment outcome, compared with less than 5% predicted by clinical variables. In the more severely depressed patients, temperament predicted nearly 50% of the variance in treatment outcome, which is the first time that such a substantial predictor of drug response has been identified. Within depressed women, temperament also predicted response to different antidepressant drugs. The potential importance of temperament, and the need for replication of these findings is discussed.

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PMID:
8151047
[PubMed - indexed for MEDLINE]
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