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Biometals. 1994 Apr;7(2):170-6.

Structure of acinetoferrin, a new citrate-based dihydroxamate siderophore from Acinetobacter haemolyticus.

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  • 1Faculty of Pharmaceutical Sciences, Okayama University, Japan.

Abstract

From low-iron cultures of Acinetobacter haemolyticus ATCC 17906, a new hydroxamate siderophore was purified by XAD-7 adsorption followed by preparative thin layer chromatography. The siderophore, named acinetoferrin, released citric acid, 1,3-diaminopropane and (E)-2-octenoic acid upon hydrolysis with HCl, reductive hydrolysis with HI and oxidation with periodate, respectively. Structure elucidation by a combination of NMR spectroscopy and positive fast atom bombardment mass spectrometry revealed that acinetoferrin is a derivative of citric acid, both of its terminal carboxyl groups being symmetrically amide-linked with the 1-amino-3-(N-hydroxy-N-2-octenylamino)propane residues. The (E)-2-octenoic acid is novel as a component of the siderophores.

PMID:
8148619
[PubMed - indexed for MEDLINE]
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