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Evolution of drug-resistant tuberculosis: a tale of two species.
University of Colorado School of Medicine, Denver, CO.
The history of the disease tuberculosis is briefly discussed. Now human societal failures have potentiated the evolution of drug-resistant strains of the tubercle bacillus in the United States and around the world. Until recently, this evolutionary change largely posed a threat to the health and survival of the individual in whom inadequate therapy promoted the drug resistance. However, the human immunodeficiency virus epidemic threatens to promote wholesale transmission of multidrug-resistant tuberculosis with the potential for immense morbidity and mortality. Reinforced treatment and control programs for tuberculosis are vital.
PMID: 8146134 [PubMed - indexed for MEDLINE]
PMCID: PMC43383
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Cited by 9 PubMed Central articles
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Tuberculosis drug resistance mutation database.
Sandgren A, Strong M, Muthukrishnan P, Weiner BK, Church GM, Murray MB.
PLoS Med. 2009 Feb 10; 6(2):e2.
[PLoS Med. 2009]
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In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.
Almeida D, Nuermberger E, Tyagi S, Bishai WR, Grosset J.
Antimicrob Agents Chemother. 2007 Dec; 51(12):4261-6. Epub 2007 Oct 15.
[Antimicrob Agents Chemother. 2007]
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Transposon-5 mutagenesis transforms Corynebacterium matruchotii to synthesize novel hybrid fatty acids that functionally replace corynomycolic acid.
Takayama K, Hayes B, Vestling MM, Massey RJ.
Biochem J. 2003 Jul 15; 373(Pt 2):465-74.
[Biochem J. 2003]
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