Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Anaesthesiol. 1994 Jan;11(1):43-51.

Inhalation of nitric oxide--a new approach in severe ARDS.

Author information

  • 1Freie Universitaet Berlin, Universitaetsklinikum Rudolf Virchow, Klinik für Anaesthesiologie und operative Intensivmedizin, Germany.

Abstract

Pulmonary hypertension due to increased pulmonary vascular resistance, and hypoxaemia based on an elevated intrapulmonary shunt are important pathophysiological features of the adult respiratory distress syndrome (ARDS). Systemically infused vasodilators reduce pulmonary hypertension but also decrease mean systemic arterial pressure and impair pulmonary gas exchange because of their global vasodilatory effects on the systemic and pulmonary circulation. Recently, inhaling low concentrations of the gas nitric oxide (NO), an important endothelium-derived relaxing factor which is rapidly inactivated by binding to haemoglobin, has been shown to induce selective vasodilation of ventilated lung regions. Thus, inhaled NO reduces pulmonary hypertension in severe ARDS and improves arterial oxygenation by redistributing blood flow away from areas with intrapulmonary shunt to areas with a normal ventilation/perfusion ratio.

PMID:
8143713
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk