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FEBS Lett. 1994 Mar 21;341(2-3):141-5.

How does NO activate hemeproteins?

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  • 1Hematology Division, University of Texas Health Science Center at Houston 77030.


NO was reported to activate guanylate cyclase and, recently, prostaglandin H synthase. NO interaction with the heme component in different hemeproteins is determined by ligand property, electronic configuration of the heme iron and the specific effects contributed by the protein structure. It is found that although NO interaction with the free heme provides some common rules of interaction, the consequences of NO binding to different hemeproteins should be dealt with individually.

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