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Dermatology. 1994;188(2):94-9.

DNA flow-cytometric analysis of basal cell carcinomas and its relevance to their morphological differentiation: a retrospective study.

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  • 1Clinique Dermatologique, Centre Hospitalier Régional et Universitaire, Rouen, France.


DNA flow cytometry (FCM) was performed on archived material of 82 basal cell carcinomas (BCC), using Hedley's technique. Sixty-five samples were analysed. Biopsy samples were classified in five groups depending on their morphological differentiation: solid, cystic, adenoid, keratotic and metatypical. Two parameters were studied: proliferative index and DNA index. Statistical analysis revealed that BCC with keratinizing or metatypical differentiation had a greater amount of aneuploidy when compared with BCC without particular differentiation (solid and cystic) or aneuploid differentiation (p < 0.001). The proliferative indices were significantly different in the four groups. DNA FCM of BCC confirms the value of morphological classifications and gives another example of aneuploidy in a tumour with low aggressiveness.

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